Plain-English translation of NCT03450603 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are trying to understand why some people with COPD experience sudden, severe flare-ups while others remain stable. This study will collect blood samples and genetic information from about 200 people with COPD — both those whose disease is stable and those currently experiencing a flare-up — to identify genetic markers that predict who is most at risk for serious exacerbations.
COPD flare-ups can be life-threatening and significantly impact quality of life, but doctors cannot yet predict who will have the most serious episodes. By identifying genetic risk factors, researchers hope to develop personalized prevention strategies and more intense monitoring for high-risk patients.
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You will visit the hospital for lung function testing and to have a blood sample drawn for genetic analysis. The study compares people whose COPD is stable (no flare-ups in the past three months) with those currently experiencing a flare-up, so your participation involves a single visit or possibly a follow-up visit depending on your COPD status. The researchers will also review your medical history to understand your disease progression.
AI-generated summary from trial data · Jun 20, 2026 · Not medical advice
China
Enrollment target
~200 participants
Started
December 2017
Primary completion
December 2027
Age range
40 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Yue Zhang
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.