Plain-English translation of NCT03472664 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial examined whether a Modified Mediterranean-Ketogenic Diet could help people with mild cognitive impairment (early memory problems that may lead to Alzheimer's disease). Researchers compared this diet—which is low in carbohydrates and high in healthy fats—with a traditional heart-healthy, low-fat diet over four months. The study looked at whether the diet could improve thinking and memory, change brain markers related to Alzheimer's, and improve blood flow in the brain.
Scientists know that what we eat may affect brain health and how Alzheimer's disease develops. This trial was designed to test whether changing diet could slow down or improve memory problems in people with early cognitive decline, and to understand the specific ways that diet affects the brain.
Participants were randomly assigned to follow either a modified Mediterranean ketogenic diet (keeping daily carbohydrates below 20 grams) or a standard heart-healthy diet for four months. Both groups received personalized meal plans and guidance from a dietitian, with the goal of eating approximately the same total calories as they normally did. Participants attended in-person visits where they received nutrition support, food supplies like olive oil, and regular check-ins to monitor how well they followed the diet. Throughout the study, researchers conducted memory tests, blood tests, and brain imaging scans to see how the diets affected their thinking, brain health markers, and blood flow in the brain.
AI-generated summary from trial data · Aug 15, 2026 · Not medical advice
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