Plain-English translation of NCT03491761 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether platelet-rich plasma (PRP)—an injection made from your own blood—works better than hyaluronic acid (a gel-like injection) for treating knee osteoarthritis. Both treatments involve injecting medication directly into the knee joint. Researchers will measure whether either treatment helps reduce pain and protect the cartilage in your knee over 12 months.
Knee osteoarthritis causes pain and damage to the cartilage that cushions your joints. Current treatments like gel injections help some patients, but doctors want to know if using a concentrated blood product might work even better to reduce pain and slow cartilage breakdown.
You likely qualify if…
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If you qualify, you will have blood work done to check your baseline health. Then you will be randomly assigned to receive either a platelet-rich plasma injection or a hyaluronic acid injection into your knee—both procedures take about 20–30 minutes and use the same injection technique. You will return for MRI scans and pain assessments at baseline and 12 months to see how well the treatment worked for you.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States