Plain-English translation of NCT03496792 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand a specific reflex in your body called the venous distension reflex — essentially how your veins respond to changes in blood flow and help control your blood pressure. This study will test this reflex by having you stand up and tilt on a special table, and sometimes applying gentle pressure or suction to your legs, while doctors measure your blood pressure and nerve activity. They're comparing people whose blood pressure goes up when standing to those whose stays steady, to learn how this reflex works differently in each group.
About two-thirds of your blood lives in your veins, and how these veins respond to changes can dramatically affect your blood pressure, especially when you move from lying down to standing up. By understanding this venous reflex system better, doctors hope to explain why some people experience blood pressure changes with position and develop better ways to manage it.
You likely qualify if…
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You will visit the research center for testing sessions where doctors will measure your blood pressure and nerve activity in your legs using special sensors. During these visits, you'll lie down and stand up on a tilting table while they monitor your body's responses. They may also apply a blood pressure cuff to your thigh and use gentle suction on your lower leg to see how your body reacts. The sessions involve different combinations of tilting, pressure, and suction to understand how your venous reflex system works.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
United States
Sponsor
Milton S. Hershey Medical Center
Enrollment target
~30 participants
Started
March 2020
Primary completion
November 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Jian Cui, PhD
Penn State College of Medicine
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.