Plain-English translation of NCT03516461 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing fecal microbiota transplantation (FMT) — a procedure where healthy gut bacteria from a donor are transplanted into your intestines — to help heal bowel damage caused by radiation therapy for cancer. The study compares patients who receive FMT with those who receive standard care alone. Researchers will track how this treatment affects your gut bacteria, blood chemistry, and symptoms over 12 weeks.
Radiation therapy can severely damage the intestines, causing long-term pain, bleeding, and digestive problems. This treatment exists because restoring healthy gut bacteria may help your intestines heal and reduce these painful symptoms.
You will be admitted to the hospital and randomly assigned to either receive the gut bacteria transplant procedure or standard care for radiation bowel damage. You will have blood tests, a scope examination of your intestines, and questionnaires at the start and end of the study. You'll be followed for at least 12 weeks, during which researchers will analyze your gut bacteria and blood chemistry to see how the treatment is working.
AI-generated summary from trial data · Sep 24, 2026 · Not medical advice
China
Sponsor
The Second Hospital of Nanjing Medical University
Collaborators
Jiangxi Provincial Cancer Hospital
Enrollment target
~70 participants
Started
January 2018
Primary completion
July 2025
Age range
18 Years – 85 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Faming Zhang, MD; PHD
The Second Hospital of Nanjing Medical University