Plain-English translation of NCT03522064 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing a combination treatment using testosterone injections (in a method called bipolar androgen therapy) paired with carboplatin chemotherapy. The trial focuses on men whose prostate cancer has become resistant to standard hormone-lowering treatments and who have specific DNA repair gene mutations. Researchers believe this combination may help the cancer become sensitive to treatment again and improve quality of life.
Most men with advanced prostate cancer eventually develop resistance to hormone therapy, and new treatment options are needed. Early research suggests that cycling testosterone levels combined with chemotherapy might work better in patients with certain genetic changes, but doctors need to test this approach carefully to understand who benefits most and how it affects the cancer.
You likely qualify if…
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You would receive testosterone injections every 4 weeks along with your ongoing hormone therapy, plus carboplatin chemotherapy on a schedule determined by your doctor. You'll have blood tests and imaging scans to monitor how the cancer responds and track side effects. The study involves regular clinic visits to assess your health, quality of life, and how the treatment is working, with the goal of understanding whether this combination helps men with your type of cancer.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
Australia
Phase
Testing effectiveness
Sponsor
St Vincent's Hospital, Sydney
Enrollment target
~30 participants
Started
July 2018
Primary completion
September 2026
Age range
18 Years and older
Sex
Male only
Last updated on clinicaltrials.gov in April 2026.
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Central contact
Robert Kent
St Vincent's Hospital
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