Plain-English translation of NCT03552705 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 2 โ Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
When you tear your ACL (a key ligament in the knee), your joint bleeds and becomes inflamed, which can lead to arthritis years later. This study is testing whether , an FDA-approved medication that reduces bleeding, can also reduce inflammation and protect your joint health after ACL injury and surgery. The researchers want to see if this medication might help prevent or delay arthritis in people like you.
People who injure their ACL are at high risk of developing arthritis within just 10 years. There aren't many proven ways to prevent this outcome yet, so researchers are testing whether controlling bleeding and inflammation right after surgery with this medication could protect your joint long-term.
You likely qualify ifโฆ
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You would receive the medication (or placebo) in two ways: intravenously during your ACL reconstruction surgery, and then as an oral medication taken three times daily for 5 days after surgery. The study team would monitor your knee's healing and inflammation over time using imaging and blood tests to see if the medication helps protect your joint health and reduces your risk of future arthritis.
AI-generated summary from trial data ยท Jun 27, 2026 ยท Not medical advice
United States