Plain-English translation of NCT03555851 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research trial is studying a medicine called that is given after stem cell transplants to help prevent a serious complication called graft-versus-host disease. The researchers want to understand why this medication works better for some patients than others by looking at genetic differences in the patient and donor. By studying genes and measuring how much of the medication is in the body, they hope to predict who will benefit most and who might experience side effects.
After a stem cell transplant, the new immune cells sometimes attack the patient's body, causing a painful and sometimes life-threatening condition. This medication is used to prevent that, but it doesn't work the same way in everyone. This study exists to figure out which genetic factors predict whether this treatment will be effective and safe for each individual patient.
You likely qualify if…
You likely don't qualify if…
If you are a transplant recipient, you will receive as part of your standard transplant care, and researchers will collect blood samples before and after your transplant to measure the medication levels and study your genes. If you are a donor, you will provide a blood or saliva sample for genetic testing. Both participants and donors will have their medical information and laboratory results monitored throughout the study to track how well the treatment works and what side effects occur.
AI-generated summary from trial data · Aug 2, 2026 · Not medical advice
United States
Sponsor
Wake Forest University Health Sciences
Collaborators
Atrium Health Levine Cancer Institute
Enrollment target
~120 participants
Started
July 2018
Primary completion
October 2033
Age range
18 Years and older
Last updated on clinicaltrials.gov in July 2026.
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Central contact
Elizabeth Parke
Wake Forest University Health Sciences
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