Two treatment approaches after adrenal cancer surgery to prevent recurrence

Plain-English translation of NCT03583710 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated August 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

After surgery for adrenal cortex cancer, this trial tests whether taking alone for 2 years works better than taking combined with four rounds of chemotherapy ( and ) to prevent the cancer from coming back. The trial will randomly assign patients to one of these two treatment groups and follow them to see which approach helps people stay cancer-free longer.

Adrenal cortex cancer is aggressive and often comes back even after surgery. Doctors want to know if adding chemotherapy to the standard medication treatment () can better reduce the chances of recurrence and help patients live longer.

Do you qualify?

You likely qualify if…

you have been diagnosed with stage I, II, or III adrenal cortex cancer that was surgically removed within the past 90 days
your cancer has a high risk of returning based on tumor characteristics (like a high Ki67 score) and the extent of surgical removal
you have had imaging scans (CT, MRI, or PET-CT) in the past 8 weeks showing no obvious signs of cancer spread
you are in generally good health and able to tolerate the treatments and follow the study plan
you are not pregnant or breastfeeding

You likely don't qualify if…

you have significant kidney disease or liver disease that would make these treatments unsafe
you have very low blood cell counts (low neutrophils or platelets)
you have a history of other cancers in the past 2 years (with limited exceptions)
you have heart failure or severely reduced heart function
cancer was found to be left behind after your surgery that could not be removed

What participation looks like

You will be randomly assigned to either take as a daily pill for 2 years, or take the same pill plus receive four rounds of intravenous chemotherapy (given over 2-3 days every 3 weeks for about 3 months). You'll have regular clinic visits and imaging scans to monitor your health, and you'll complete quality-of-life surveys at several time points. The study will follow you for several years to track whether your cancer comes back.

AI-generated summary from trial data · Aug 26, 2026 · Not medical advice

Two treatment approaches after adrenal cancer surgery to prevent recurrence

What is this trial?

Do you qualify?

What participation looks like

Trial locations