Plain-English translation of NCT03633162 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This is a long-term study following three generations of women—grandmothers, mothers, and children—born in Guangzhou, China. Researchers want to understand how a grandmother's health, lifestyle, and genetic background influence her grandchildren's development and risk for common diseases like obesity and immune problems. By collecting detailed information about each generation, scientists hope to discover new patterns in how family health traits are passed down.
Scientists recently discovered that mothers can pass protective immune factors to babies during pregnancy in ways that don't follow traditional genetics rules. This study exists to explore whether grandmothers' health and environment also influence their grandchildren's wellbeing—something that hasn't been well studied in Asia before.
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You would meet with researchers who collect detailed information about your health history, lifestyle habits, diet, mental health, and family background. Over time, the study team will check in with you and your family to monitor everyone's health and track common conditions. You'll be part of a rare three-generation family study that helps scientists understand how health runs in families.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
China
Sponsor
Guangzhou Women and Children's Medical Center
Collaborators
Children's Hospital Medical Center, Cincinnati, University of Birmingham
Enrollment target
~5,000 participants
Started
May 2018
Primary completion
December 2038
Age range
36 Years – 100 Years
Sex
Female only
Last updated on clinicaltrials.gov in September 2026.
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Central contact
Xiu Qiu, PhD
Guangzhou Women and Children's Medical Center, China
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