Take experimental medications combined with standard chemotherapy for leukemia

Back to Acute Lymphoblastic Leukemia, Pediatric trials

What is this trial?

This is a large international study testing whether adding newer medicines—including and —to standard chemotherapy can help children and teenagers with acute lymphoblastic leukemia (a type of blood cancer) do better. Doctors already have successful standard treatments, but this trial is checking whether these additional medications can improve survival even further, especially for patients at higher risk.

While current chemotherapy treatments have greatly improved outcomes for children with leukemia, some patients still relapse or face poor outcomes. This trial is exploring whether adding targeted immunotherapy medicines alongside standard chemotherapy can help prevent relapse and improve long-term survival for children at higher risk of the disease returning.

Do you qualify?

You likely qualify if…

you have been newly diagnosed with acute lymphoblastic leukemia or a related blood cancer
you are under 18 years old (up to 17 years and 365 days) at the time of diagnosis
you are enrolled at a hospital or medical center participating in this study
you have not received chemotherapy treatment before your diagnosis
you and your parent or guardian have signed consent forms agreeing to participate

You likely don't qualify if…

you have a specific genetic type of leukemia called Philadelphia chromosome positive (Ph+ ALL)
you received high-dose steroid medication in the month before diagnosis
you have already started treatment at another hospital or clinical trial
you have a serious underlying medical condition that would make this intensive treatment unsafe
you are pregnant, breastfeeding, or unwilling to use reliable contraception during treatment

What participation looks like

Over about two years, you would receive intensive chemotherapy treatment given in phases: induction (starting within weeks of diagnosis), consolidation, reinduction, and maintenance therapy. Depending on your risk group, you may be randomly assigned to receive one of the experimental medications added to your standard chemotherapy regimen. You will have frequent hospital visits for medications, blood tests, spinal taps, and imaging scans to monitor how well the treatment is working and check for side effects.

Testing new medicines to improve treatment for childhood blood cancer

What is this trial?

Do you qualify?

What participation looks like

Trial locations(115 sites)