Plain-English translation of NCT03671889 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a device called ExAblate that uses focused ultrasound waves to temporarily open the blood-brain barrier—a protective wall in your brain that normally blocks most medicines. Researchers want to see if opening this barrier safely in people with Alzheimer's disease can help treatment work better. You would receive three ultrasound procedures over time, with careful monitoring to make sure the treatment is safe.
The blood-brain barrier is very effective at protecting the brain, but it also makes it hard for Alzheimer's medicines to reach the disease. This trial is testing whether temporarily opening this barrier could allow treatments to work more effectively.
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You would visit the research clinic up to 8 times across multiple centers in the United States. During your visits, you would receive three ultrasound procedures on your brain while lying in an MRI machine—the procedure uses sound waves guided by imaging to safely open the barrier in specific areas. You would also have brain scans, memory testing, and blood tests, and may need a lumbar puncture (spinal tap) to collect fluid from around your spine for research purposes.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States