Plain-English translation of NCT03681652 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Crohn Disease research guide →This trial is tracking children with Crohn's disease who have recently had surgical removal of part of their intestines. The study compares two different types of preventive medications—thiopurines (like or 6MP) and anti-TNF drugs—to see which one is better at keeping the disease from returning after surgery.
After bowel surgery for Crohn's disease, the illness often comes back and may require more surgery. While adult studies have shown that anti-TNF medications may work well to prevent this recurrence, there is very little evidence about which preventive treatment works best in children. This trial aims to fill that gap.
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You would continue taking your prescribed preventive medication (either a thiopurine or ) as part of your regular care. The study team will follow your progress over time through clinic visits, blood tests, and a colonoscopy (a scope to look inside your bowel) about 6–9 months after surgery to check if the disease is returning. The study involves tracking your health outcomes without changing your regular treatment plan.
AI-generated summary from trial data · Jun 17, 2026 · Not medical advice
Israel
Enrollment target
~100 participants
Started
February 2019
Primary completion
December 2026
Age range
6 Years – 18 Years
Last updated on clinicaltrials.gov in May 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Amit Assa, MD
Schneider Children's Medical Center, Israel
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.