Plain-English translation of NCT03688100 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Heart failure research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial studied two different ways to treat depression in people living with advanced heart failure: one group received antidepressant medication prescribed by their doctor, while the other group received behavioral activation therapy, which is a type of talk therapy focused on helping people gradually return to meaningful activities. The study tested which approach worked better at reducing depressive symptoms and improving quality of life over one year.
Depression is very common in people with advanced heart failure and can make their condition worse, but doctors weren't sure which treatment approach—medication or therapy—was most effective for these patients. This trial aimed to find out which option helps people feel better and stay healthier.
Participants were assigned to receive either antidepressant medication or behavioral activation therapy (talk therapy). Both groups had an initial 50-minute in-person session, then either received with weekly phone calls for 12 weeks followed by monthly calls, or received 12 weekly talk therapy sessions by phone followed by 3 monthly maintenance sessions. Participants were followed for one year total, with check-ins at 3, 6, and 12 months to assess how they were doing.
AI-generated summary from trial data · Oct 12, 2026 · Not medical advice
United States