Plain-English translation of NCT03741426 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing several new or repurposed medications—including , , , and —in people with kidney cancer who are scheduled for surgery to remove their tumor. You would take or receive one of these medications for at least 2 weeks before your surgery, and researchers would measure whether the treatment affects your tumor and how your body responds to it.
Most kidney cancers are treated with surgery alone, but researchers want to know if giving medication before surgery can slow the cancer down or make the tumor easier to remove—and whether these new treatments are safe enough for patients to tolerate.
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You would have a 28-day screening period with blood tests and imaging, then take one of the experimental medications by mouth or receive an injection, continuing until about 1–2 days before your scheduled kidney surgery. During this time, you would have imaging scans (MRI) to see how your tumor responds. After surgery, you would have follow-up visits with your surgical team at 6 weeks and 3 months as normal, and researchers would analyze your tumor tissue to understand how the medication worked.
AI-generated summary from trial data · Oct 7, 2026 · Not medical advice
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