Plain-English translation of NCT03741673 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial compares two different treatment schedules for people whose cancer has spread to the brain and need surgery. One group receives stereotactic radiosurgery (a focused type of radiation therapy) before their surgery, and the other group receives it afterward. The study wants to find out which order works better to prevent the disease from spreading further in the brain.
Currently, giving radiation therapy after surgery is the standard approach, but doctors want to know if doing it before surgery might prevent the cancer from spreading to other parts of the brain and improve outcomes for patients.
You will be randomly assigned to one of two groups. If you're in the first group, you'll receive radiation therapy within 30 days, then have surgery within 30 days after that. If you're in the second group, you'll have surgery first within 30 days, then receive radiation therapy within 30 days afterward. Both groups may receive additional radiation if the cancer returns. You'll have follow-up visits periodically after your treatment to check how you're doing.
AI-generated summary from trial data · Aug 13, 2026 · Not medical advice
United States