Plain-English translation of NCT03746769 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 1 research guide →Phase 1/2 — A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This study is testing whether gastrin, a natural hormone your gut produces, can help transplanted insulin-making cells work better after being placed into your body. Doctors will give you a single transplant of insulin-making islet cells from a donor pancreas, along with two rounds of gastrin injections (given twice daily for 30 days each). Early research suggests this medication may help your transplanted cells produce more insulin and reduce how much insulin you need to inject yourself.
There are not enough donor pancreas cells available for everyone who needs them, so researchers want to find ways to make each transplant work harder and last longer. This medication may help a smaller number of donated cells do the work of a larger number, making transplants more available to patients.
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You will receive one islet cell transplant and then two separate rounds of gastrin injections — the first starting right after your transplant and the second starting 6 months later. Each round involves twice-daily injections for 30 days. You will also take anti-rejection medications and other supportive medications for life. You'll need to visit City of Hope frequently (especially during the first year) for blood tests, checkups, and to review your blood sugar logs and medication records.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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