Plain-English translation of NCT03748446 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This early-stage trial is testing whether , a medical gas that has been safely used as an anesthetic, might help treat depression. Researchers believe works differently than traditional antidepressants by affecting a brain chemical called glutamate. The study will compare inhaling mixed with oxygen to a placebo gas mixture, both added to your regular depression treatment.
Standard antidepressants often take weeks to work and don't help about two-thirds of patients who try them. This medication targets a different pathway in the brain that may offer a faster or more effective option for people whose depression isn't adequately controlled by current treatments.
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You would visit the study site to inhale either or a placebo gas (mixed with oxygen) while continuing your regular depression medications. The study involves a small group of 20 participants and is currently recruiting. Your participation would include study visits where researchers monitor your depression symptoms and any side effects, with support from your own psychiatrist throughout the process.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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