Plain-English translation of NCT03750227 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial compares two different treatment schedules for patients with cancer that has spread to the brain. Some patients will have surgery first, followed by stereotactic radiosurgery (a focused radiation treatment) within 2 weeks. Others will receive the radiation therapy first, followed by surgery within 4 weeks. The trial is trying to figure out which order works better for keeping the cancer from coming back and for helping patients live longer.
Doctors aren't sure whether the order of radiation and surgery matters for patients with brain tumors that have spread from cancer elsewhere in the body. This trial will help determine which approach gives patients the best chance of avoiding tumor recurrence, living longer, and maintaining their quality of life.
You likely qualify if…
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You will be randomly assigned to receive either surgery first or radiation therapy first. Before radiation, you'll have imaging scans (CT or MRI) for treatment planning. During surgery, doctors will collect tissue and fluid samples for research. Throughout the study, you'll have regular MRI scans and optional blood draws to monitor your progress. You'll also complete quality-of-life surveys and attend follow-up visits either at the clinic or with your local doctor, depending on what's convenient for you.
AI-generated summary from trial data · Jul 12, 2026 · Not medical advice
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