Plain-English translation of NCT03753412 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is watching how people recover after severe heart or lung failure that required a mechanical heart-lung support machine called ECMO. Researchers want to understand how this critical illness affects muscle strength and everyday function, and what helps patients recover better. The study will measure muscle size using ultrasound and ask patients about their physical ability and quality of life over time.
When people survive severe heart or lung failure, they often lose significant muscle mass and strength — sometimes even after relatively straightforward surgeries. This weakness can last long after leaving the hospital and affects quality of life, but doctors don't yet fully understand what causes it or how to help patients recover best.
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You would be observed during your recovery from severe heart or lung failure while receiving ECMO support. Researchers would use ultrasound to measure your thigh muscle size at different time points, collect biological samples to study at the molecular level, and ask you questions about how well you can function and your quality of life as you recover. The study follows patients over their recovery period in the hospital and beyond.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United Kingdom
Collaborators
Queen Mary University of London
Enrollment target
~100 participants
Started
April 2019
Primary completion
September 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Mark Griffiths, PhD FRCP
Substantive Employee and primary supervisor to PhD student
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