Plain-English translation of NCT03759522 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This research study uses a special type of brain scan called PET imaging with a tracer called [F-18]DPA-714 to look for signs of inflammation in the brains of people with chronic pain and fatigue conditions. The tracer highlights activated immune cells in the brain that may be contributing to symptoms like pain and tiredness. Researchers will compare results from people with fibromyalgia, chronic fatigue syndrome, and multiple sclerosis to healthy volunteers to see if these conditions involve more brain inflammation than expected.
Doctors don't fully understand why some people develop chronic pain and extreme fatigue, but they suspect brain inflammation might play a role. This study aims to see if measuring brain inflammation with advanced imaging could help explain these conditions and eventually lead to better treatments.
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You will visit the research center for a brain imaging appointment where you'll undergo a PET/MRI scan—a combined imaging procedure that takes pictures of your brain while you lie in the scanner. The scan is painless and non-invasive. You may also have blood work done and answer questions about your symptoms. The entire visit typically takes a few hours, and there is no ongoing medication or long-term commitment required.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States