Plain-English translation of NCT03775577 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to understand why people with heart failure—especially a type called heart failure with preserved ejection fraction—struggle to exercise and do everyday activities. This study uses special imaging (magnetic resonance) to measure how energy is produced and used in the heart muscle and leg muscles. By understanding these differences, doctors hope to develop better treatments to help patients stay active.
People with heart failure often feel exhausted when exercising, even when their heart's pumping ability seems normal on standard tests. Doctors don't fully understand why this happens at the muscle level. This study aims to uncover what's going wrong with how muscles convert food into usable energy, which could lead to new ways to help patients.
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You would visit Johns Hopkins University for imaging scans using a special machine that takes pictures of your heart and leg muscles to measure energy levels. You would also likely undergo exercise tests to see how your muscles work during activity. The study compares people with different types of heart failure, high blood pressure, and healthy volunteers to understand the differences in muscle energy use.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States
Sponsor
Johns Hopkins University
Collaborators
National Heart, Lung, and Blood Institute (NHLBI)
Enrollment target
~130 participants
Started
April 2017
Primary completion
August 2027
Age range
21 Years and older
Last updated on clinicaltrials.gov in March 2026.
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Central contact
Matthew Kauffman
Johns Hopkins University
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