Plain-English translation of NCT03781765 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
Researchers want to understand how two common ADHD medications — and — affect how a child's brain responds to rewards. Some animal research suggests that stimulant medications like might prime the brain in ways that could increase addiction risk, while non-stimulant medications like might have protective effects. This study will use brain imaging to see if these two medications actually work differently in children.
Children with ADHD have a higher chance of developing substance use problems later in life, possibly because their brain's reward system works differently. Understanding how ADHD medications affect this reward system could help doctors choose safer treatments and prevent addiction in high-risk kids.
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You would take one of the two medications for about 3 weeks total (starting at a lower dose and increasing it). During this time, you would visit the research clinic for brain imaging scans and other tests to measure how your brain responds to rewards. The researchers will also ask you and your parents questions about your behavior and do some computer-based tasks to see how the medication affects your thinking and reward sensitivity.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States
Phase
Post-approval monitoring
Sponsor
Icahn School of Medicine at Mount Sinai
Collaborators
National Institute on Drug Abuse (NIDA)
Enrollment target
~44 participants
Started
June 2019
Primary completion
September 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
7 Years – 12 Years
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Beth Krone, PhD
Icahn School of Medicine at Mount Sinai
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.