Plain-English translation of NCT03784924 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is testing whether adding a prostate MRI scan to existing blood and urine biomarker tests can more accurately identify men with high-grade prostate cancer. The study will enroll nearly 950 men who are at risk for prostate cancer and are already scheduled for a prostate biopsy as part of their routine care. By combining MRI imaging with these biomarkers, doctors hope to better predict who truly needs a biopsy and avoid unnecessary procedures.
Current blood tests like PSA can be unreliable—they often suggest cancer is present when it actually isn't, leading to unnecessary biopsies and patient anxiety. This study aims to see if adding an MRI scan to these tests can improve accuracy and help doctors focus biopsies only on men who truly need them.
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As a participant, you would donate blood and urine samples, complete a prostate MRI scan, and have a digital rectal exam as part of your already-scheduled biopsy appointment. The study will collect these samples and imaging results before your biopsy, and researchers will follow your care over time to track whether changes in these biomarkers and MRI findings predict whether you develop high-grade prostate cancer. Your participation helps build a valuable research database that will help future patients avoid unnecessary testing.
AI-generated summary from trial data · Aug 23, 2026 · Not medical advice
United States
Sponsor
University of Michigan
Collaborators
The University of Texas Health Science Center at San Antonio, University of Alabama at Birmingham
Enrollment target
~950 participants
Started
February 2019
Primary completion
June 2028
Age range
18 Years and older
Sex
Male only
Last updated on clinicaltrials.gov in August 2026.
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Central contact
Jackie Dahlgren
University of Michigan
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