Plain-English translation of NCT03804931 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing fecal microbiota transplantation (FMT), a procedure where healthy bacteria from a donor's stool are carefully processed and placed into your intestines. The goal is to restore balance to your gut bacteria and help control ulcerative colitis symptoms. Researchers want to see if this treatment works better than a placebo infusion or traditional medications like 5-Aminosalicylic acid.
Ulcerative colitis happens when the balance of bacteria in your gut gets disrupted, causing inflammation and painful symptoms. This treatment is being tested because early research suggests that restoring healthy bacteria might help calm that inflammation and give patients relief when other treatments haven't worked well enough.
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If you join, you will receive at least two transplant procedures where the healthy bacteria are infused into your intestines. You'll be randomly assigned to receive either the active treatment, a placebo saline infusion, or continue traditional medications. You'll come back for follow-up visits for at least three months so researchers can track how you're doing and whether your symptoms improve.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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