Plain-English translation of NCT03821623 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , a naturally occurring B-vitamin supplement, can lower blood pressure and reduce stiffness in your arteries. You would take the medication or a placebo pill twice daily for 3 months, and researchers would measure your blood pressure and artery health before and after. A smaller pilot study showed promising results, so this larger study aims to confirm whether this treatment really works.
High blood pressure and stiff arteries are major risk factors for heart disease and stroke, especially as we age. Current treatments don't work well for everyone, so researchers are exploring whether this medication—which mimics some of the beneficial effects of calorie restriction—might offer a new option for people with mildly elevated blood pressure.
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You will be randomly assigned to take either the B-vitamin supplement or a placebo pill twice per day for 3 months. Before the study starts, you'll have screening visits that include blood tests, blood pressure checks, heart tests, and an exercise stress test. During the 3-month treatment period, you'll have follow-up visits to check your blood pressure, take blood samples to measure how the medication is working in your body, and assess how well you're tolerating the treatment. At the end, you'll have final tests to see whether your blood pressure or artery stiffness has improved.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United States