Plain-English translation of NCT03821857 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Alzheimer Disease research guide →Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This study is investigating how hormones may affect brain aging and memory loss in women over 60. Researchers will use special brain imaging scans — including MRI and PET scans — to look for signs of changes associated with memory problems. By studying women specifically, the researchers hope to better understand why memory loss affects men and women differently as they age.
Memory loss and Alzheimer's disease affect millions of people, but scientists don't yet fully understand why the disease progresses differently in women than in men. This study aims to fill that gap by examining how hormone-related changes in women's bodies may influence brain aging and memory loss over time.
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If you are at the Rochester location, you will have 2 to 3 clinic visits where you'll complete thinking and memory tests, answer health questionnaires, have blood drawn, and undergo brain imaging scans (MRI and PET scans). If you are at the Jacksonville location, you will have 1 to 3 visits focused on physical function testing and the same brain imaging scans. All visits are scheduled by invitation, and you will be returning to Mayo Clinic as a previous study participant.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
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