Plain-English translation of NCT03823534 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether adding (an anti-inflammatory medication) to standard opioid pain relievers helps control pain better after preventive leg bone surgery. Patients with cancer that has spread to their leg bones often need surgery to prevent future fractures. The study wants to see if this medication combination reduces pain while also potentially lowering the need for opioids.
The opioid epidemic has made doctors cautious about prescribing too many narcotic painkillers. This medication is not typically used after bone surgery because doctors worry it might slow healing — but in preventive surgery (where no fracture exists), there's no healing to slow down, so it may be safe and effective.
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You would undergo the planned preventive leg bone surgery at St. Louis University. After surgery, you'll receive pain medications according to which group you're assigned to — either the standard opioid approach alone, or opioids combined with the anti-inflammatory medication. Hospital staff will monitor your pain levels and how well the treatment works. Most of the active treatment phase lasts about 24 hours after surgery, with a prescription for pain medication to take at home after discharge.
AI-generated summary from trial data · Jul 1, 2026 · Not medical advice
United States