Plain-English translation of NCT03825861 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a chemotherapy combination called given before surgery in people with locally advanced stomach cancer. The goal is to see if this medication — delivered through a long-term catheter (a thin tube placed in a vein) — can shrink the tumor and improve outcomes before the surgeon removes it. Researchers will also watch closely for any side effects.
Stomach cancer that has grown beyond the stomach wall or spread to nearby lymph nodes is very serious. This trial exists to find out whether giving this medication before surgery — rather than after — can help more patients survive and live longer.
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You would receive the chemotherapy through a catheter (a small tube in your vein) every two weeks for four months — a total of eight treatments. Between four and eight weeks after your last chemotherapy dose, you would have scans and tests to see how well the medication worked. If the cancer has not spread further, you would then have surgery to remove the tumor. After surgery, you would be followed for five years to monitor how well you're doing and whether the cancer returns.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
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