Plain-English translation of NCT03842475 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 2 research guide →This research study is trying to understand why weight loss surgery (specifically Roux-en-Y gastric bypass) helps some people with type 2 diabetes and excess weight lose weight and improve their blood sugar control—sometimes even making their diabetes disappear. The researchers will study fat distribution, genetic factors, and how your body responds to food before and after surgery to create a predictor that could help doctors know in advance which patients will benefit most from this type of surgery.
Many people with type 2 diabetes and obesity improve dramatically after weight loss surgery, but not everyone does. Doctors currently have no reliable way to predict ahead of time who will see their diabetes go away and who won't—so this research aims to identify biological markers that could help make that prediction.
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If you're in the surgery group, you'll have blood tests and body composition scans before your scheduled weight loss surgery, and then again after surgery to track changes in your diabetes, hormones, and fat distribution. The healthy volunteer comparison group will complete similar measurements once to provide a baseline for comparison. The study collects genetic samples and measures how your body responds to a meal, in addition to standard medical assessments.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
United Kingdom
Sponsor
Imperial College London
Collaborators
National Institute for Health Research, United Kingdom
Enrollment target
~210 participants
Started
October 2018
Primary completion
January 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 80 Years
Last updated on clinicaltrials.gov in April 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Julia S Kenkre, MB BChir
Imperial College London
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.