Recruiting

Brain training exercises to prevent memory loss in older adults

Plain-English translation of NCT03848312 on ClinicalTrials.gov ↗ · Source last updated September 2024 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This research study is testing whether a specific type of computerized brain training — called speed of processing training — can help prevent memory problems and early dementia in adults age 65 and older. Researchers want to see if practicing these brain exercises over several months can reduce your risk of developing mild cognitive impairment or dementia. You would complete training sessions on a computer, both at home and during supervised visits.

Memory loss and thinking problems are common concerns as we age, but there are limited proven ways to prevent them. This treatment is designed to challenge and strengthen the brain's processing speed, which may help keep your mind sharp and reduce your risk of developing serious memory problems later on.

Do you qualify?

You likely qualify if…

you are 65 years of age or older
you speak and understand English or Spanish
you have normal or near-normal memory and thinking skills (no diagnosis of mild cognitive impairment or dementia)
you can see a computer screen clearly, hear conversation, and use a computer mouse or touch screen
you are willing and able to complete all study activities over the full length of the study

You likely don't qualify if…

you have been diagnosed with mild cognitive impairment, dementia, stroke, or a brain disorder that affects thinking
you are currently taking dementia medications such as Namenda, Donepezil, Aricept, or similar drugs
you have completed 10 or more hours of computerized brain training programs (like Lumosity or Brain HQ) in the last 5 years
you have vision, hearing, or movement problems that would prevent you from using a computer
you have severe depression or other unstable health conditions that might affect your ability to participate

What participation looks like

You would complete an initial screening appointment to confirm you are eligible for the study. Then you would be randomly assigned to one of two groups that do slightly different computerized brain activities. You would attend at least two supervised training sessions in person, then complete additional 25 training sessions at home over 3 to 5 months (about 2–3 sessions per week). You would also return for check-in visits and additional booster training sessions at 1 year and 2 years after starting. In total, the study would follow you for several years to see if the training helps protect your memory and thinking skills.

AI-generated summary from trial data · Jun 19, 2026 · Not medical advice

Brain training exercises to prevent memory loss in older adults

What is this trial?

Do you qualify?

What participation looks like

Trial locations(7 sites)