Plain-English translation of NCT03852407 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing two different ways to prepare your body before receiving a stem cell transplant from a matched donor to treat your blood cancer. Both preparation methods use chemotherapy drugs given in lower doses than standard transplant preparations, designed to be gentler while still helping your new donor cells take hold. The trial will compare how well each approach works and which one has fewer side effects.
Standard stem cell transplants use very high-dose chemotherapy that many patients—especially those over 50 or with other health conditions—cannot tolerate safely. This trial is testing whether one of these gentler preparation methods might work better or cause fewer problems than the other, so doctors can offer the safest and most effective option to more patients who need a transplant.
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If you enroll, you will be randomly assigned to receive one of two preparation regimens: one group receives three chemotherapy drugs over several days, while the other receives two chemotherapy drugs plus an immune-suppressing medication. You will then receive your donor's stem cells. The study involves visits at the hospital for treatment and close monitoring, followed by outpatient follow-up visits. You will be followed for at least 5 years after your transplant, with additional long-term follow-up for up to 10 more years to track how well you are doing, watch for any late side effects, and monitor your disease status.
AI-generated summary from trial data · Jun 15, 2026 · Not medical advice
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