Plain-English translation of NCT03868150 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
During your open-heart surgery, doctors will gently stimulate part of your heart for 30 seconds using a pacemaker to see how easily it develops an irregular rhythm. If your heart shows this sensitivity, you'll have a 50% chance of receiving Amiodarone, an FDA-approved medication, to help prevent irregular heartbeat problems after surgery. The goal is to identify patients at highest risk and protect them with preventive treatment.
Irregular heartbeats are common after open-heart surgery and can cause serious complications. This trial is testing whether identifying which patients' hearts are most prone to this problem during surgery could help doctors prevent it by starting the medication before it happens.
You likely qualify if…
You likely don't qualify if…
During your scheduled open-heart surgery, the surgeon will perform a quick 30-second pacemaker stimulation test on your heart before connecting you to the heart-lung machine—this adds only about 60 seconds to your operation and doesn't require any tissue or blood samples. If your heart shows sensitivity to irregular rhythms during this test, you'll randomly receive either the preventive medication or standard care, and your recovery will otherwise follow the normal post-surgery plan.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
United States