Plain-English translation of NCT03876223 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is looking at a specific heart condition called coronary microvascular dysfunction—problems with the tiny blood vessels in your heart—that can cause chest pain and heart symptoms without any blockages in the larger heart arteries. Researchers want to understand how this condition damages the heart muscle and leads to heart failure, so they can find ways to stop it from getting worse.
Many people, especially women, experience chest pain and heart symptoms but their doctors don't find any blockages in their main heart arteries. This study exists because doctors still don't fully understand what's happening in these tiny blood vessels or how to prevent the condition from developing into heart failure.
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You will undergo heart catheterization with special testing to measure how your tiny heart blood vessels respond to stress, plus blood tests to check for heart damage. You'll also have two cardiac MRI scans—one at the start and another 1–2 years later—to look for changes in your heart muscle. The entire study involves detailed measurements of how your heart responds to stress and imaging to track any progression over time.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United States