Simplified HIV treatment with two medications instead of three

This trial is testing whether dolutegravir and lamivudine—a simpler two-drug combination—can work as well as the standard three-drug HIV treatments. The study will follow 300 people with HIV who have already been on regular treatment for at least 6 months to see if this medication keeps their virus under control and is safe to use long-term.

Many people with HIV struggle with side effects from standard three-drug treatments, or have other health problems that make those medications difficult to take. This trial exists to find out whether this simpler treatment option could work for people who need an easier alternative.