Recruiting

Adding radiation therapy to a liver cancer treatment procedure

Plain-English translation of NCT03895359 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

What is this trial?

This trial is testing whether combining two treatments works better than one treatment alone for liver cancer. The standard treatment is called (TACE), which delivers chemotherapy directly to the tumor through blood vessels. This trial compares TACE alone to TACE combined with stereotactic body radiation therapy (SBRT), a focused form of radiation that targets tumors very precisely.

When liver tumors are large, the standard treatment alone doesn't work as well. Researchers believe adding focused radiation therapy might improve survival and help more patients respond to treatment.

Do you qualify?

You likely qualify if…

you have been diagnosed with primary liver cancer or cancer that has spread to the liver
you have 5 or fewer separate tumors in your liver, each measuring 25 centimeters or smaller
you are not healthy enough to have surgery to remove the cancer
your liver function tests show your liver is still working reasonably well
you are at least 18 years old and expected to live at least 6 months

You likely don't qualify if…

you have severe liver cirrhosis or liver failure
you have a tumor larger than 25 centimeters
you have had radiation therapy to this area before that would overlap with the new treatment
you are pregnant, nursing, or unwilling to use contraception during the study
your liver function is severely compromised or you have active hepatitis

What participation looks like

You will be randomly assigned to receive either the standard TACE treatment alone, or TACE combined with focused radiation therapy. Both groups will have the TACE procedure, which involves a catheter placed into blood vessels that feed the tumor. If you are in the combination group, you will also receive stereotactic body radiation therapy, which uses multiple focused radiation beams to target the cancer. The study will track how well you respond to treatment and monitor your health over time.

AI-generated summary from trial data · Jun 12, 2026 · Not medical advice

Adding radiation therapy to a liver cancer treatment procedure

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)