Plain-English translation of NCT03899883 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This is a small pilot study designed to test whether a medication called pegloticase can safely lower uric acid levels in young adults with type 2 diabetes. High uric acid is more common in young people with type 2 diabetes and may increase the risk of heart and kidney problems. The study will see if this medication can improve markers of heart and kidney health.
Young adults with type 2 diabetes face higher rates of heart disease and kidney damage compared to adults diagnosed later in life or people with type 1 diabetes. Researchers have found that high uric acid levels are linked to these complications in this population, but no one has yet tested whether lowering uric acid with this medication can help prevent these serious problems.
You would receive a single intravenous infusion of the medication over about 2 hours during one visit. The study takes place over 7 days, during which researchers will measure markers of your heart and kidney health through blood tests and imaging scans (like an MRI). This is a very short study designed mainly to see if the treatment is safe and feasible in young adults with your condition.
AI-generated summary from trial data · Jul 10, 2026 · Not medical advice
United States