Plain-English translation of NCT03910010 on ClinicalTrials.gov ↗ · Source last updated · Translation generated ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand why pain medications don't work well for everyone with fibromyalgia. This study will use brain imaging scans and psychological questionnaires to identify patterns—called biomarkers—that predict which patients will respond better to treatment. By identifying these patterns, doctors hope to eventually personalize pain management for each patient based on their unique brain and psychological characteristics.
Pain medications have not proven effective for many fibromyalgia patients, and the condition costs Canada billions of dollars annually while people continue to suffer. This research aims to find biological and psychological markers that can help doctors predict which treatments will work best for each individual patient.
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You will first complete a series of brain imaging scans (MRI) and questionnaires designed to measure your pain expectations, thoughts, and brain activity. This experimental phase compares fibromyalgia patients with healthy volunteers. After this, some fibromyalgia participants will optionally enter a second phase where they receive capsules they are told contain an approved pain medication (though they actually contain an inert substance), while others simply track their pain levels without receiving anything—this helps researchers understand how much of the treatment effect comes from expectation versus the medication itself.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Canada