Plain-English translation of NCT03920618 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Hepatitis B research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing three antiviral medications — , , and — to see which one is most effective for treating hepatitis B patients who develop acute-on-chronic liver failure, a serious and life-threatening condition. The study will compare how well each medication works and help doctors choose the best treatment option for this type of patient.
Hepatitis B-related acute-on-chronic liver failure is a very serious condition with high death rates, especially in China. While these three antiviral medications are already used as first-line treatments, there is limited data showing how well the newer medication () works specifically for this severe complication, so this trial aims to fill that gap.
You likely qualify if…
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If you join this trial, you will be randomly assigned to take one of the three antiviral medications by mouth once per day. You will take your assigned medication starting immediately and continuing long-term. The trial involves regular follow-up visits where doctors will monitor how well the medication is working, check your liver function, and watch for any side effects.
AI-generated summary from trial data · Jul 17, 2026 · Not medical advice
China
Sponsor
Third Affiliated Hospital, Sun Yat-Sen University
Enrollment target
~150 participants
Started
February 2019
Primary completion
December 2024
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
12 Years – 65 Years
Last updated on clinicaltrials.gov in November 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Wenxiong Xu, Doctor
Third Affiliated Hospital, Sun Yat-Sen University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.