Plain-English translation of NCT03921047 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is collecting blood samples from patients with acute myeloid leukemia (AML) who are receiving a stem cell transplant from a donor. The goal is to understand how your immune system—specifically a type of white blood cell called T cells—changes and rebuilds after the transplant. By studying the genetic makeup of these immune cells, researchers hope to learn more about how transplants work and whether certain patterns predict better outcomes.
When patients receive a stem cell transplant for leukemia, their immune system goes through major changes as the donor's cells take hold. Researchers don't yet fully understand exactly how these immune cells recover and whether certain patterns help fight the leukemia or cause problems. This study will help fill that knowledge gap and potentially improve how we care for transplant patients in the future.
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If you enroll, you will have blood samples taken at three time points: before your transplant, on day 100 after the transplant, and one year after the transplant. Your stem cell donor will also provide a blood sample at the time of transplant. These blood samples will be analyzed using advanced genetic testing to track how your T cells change over time. The study involves no medications or extra procedures beyond the blood draws themselves.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
University of Southern California
Collaborators
National Cancer Institute (NCI)
Enrollment target
~250 participants
Started
April 2018
Primary completion
December 2026
Age range
18 Years and older
Last updated on clinicaltrials.gov in June 2026.
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Central contact
Christine Duran
University of Southern California
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.