Plain-English translation of NCT03924791 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Sciatica is severe leg pain caused by a compressed nerve in the lower back, and it can make it hard to work or enjoy daily life. This trial compares two approaches: one group receives a transforaminal epidural injection (a targeted spinal injection with and a steroid medication) while the other group receives standard oral pain medication. The goal is to see which approach helps people stay active and comfortable during the weeks when their pain is being managed.
Most people with sciatica get better with time and conservative care, but the weeks of waiting can be very painful and cause people to miss work and social activities. Researchers want to find a better way to ease this pain during the recovery period so patients can remain active and maintain their quality of life.
You likely qualify if…
You likely don't qualify if…
If you enroll, you'll be randomly assigned to receive either the spinal injection or oral pain medication as your treatment. The study will track how well each approach works for your pain and whether it helps you stay active. You'll likely have follow-up appointments to report how you're feeling and whether your symptoms improve over time.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
Netherlands
Sponsor
C.L.A.Vleggeert-Lankamp
Collaborators
Spaarne Gasthuis, Stichting Achmea Gezondheidszor
Enrollment target
~142 participants
Started
June 2019
Primary completion
December 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in October 2023.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Carmen LA Vleggeert-Lankamp, MD Msc Ph.D
Leiden University Medical Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.