Plain-English translation of NCT03954483 on ClinicalTrials.gov β Β· Source last updated Β· Translation generated Β· How we translate trials
Read our Anxiety research guide βThis study doesn't follow the usual testing phases β it may be an observational study or a different type of research.
Researchers want to find out if they can detect a specific brain signal linked to anxiety by recording electrical activity from your outer ear canalβa simpler method than traditional brain scans. The study will test two medications that affect anxiety: triazolam and buspirone. Some participants will receive a placebo (a pill with no active ingredient) instead, so researchers can compare how each treatment affects the brain signal they're measuring.
Currently, anxiety is diagnosed based on interviews and questionnaires, which can be subjective and inconsistent. If researchers can identify a reliable biological marker for anxiety using a simple ear-based recording, it could lead to faster, more accurate diagnosis and better ways to monitor how well treatments are working.
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You will visit the research center for one session lasting about 2β3 hours. You'll take one pill (either a medication or placebo) and then have electrodes placed on your head and ear to record brain activity while you complete two tasks: one involving sitting in a moving chair and another involving a decision-making game. You'll also complete hearing and balance tests and answer questionnaires about your mood and symptoms.
AI-generated summary from trial data Β· Jun 17, 2026 Β· Not medical advice
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