Plain-English translation of NCT03957902 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing aspirin—a medication most people know as a pain reliever—to see if it might help prevent colon cancer in people who have just been diagnosed. Researchers want to figure out the right dose and understand exactly how aspirin works to protect against cancer. The study will also look at blood and urine markers to track how the medication affects your body at the cellular level.
Aspirin shows promise as a cancer-prevention tool, but doctors don't yet know the best dose to use or whether it truly works in people with newly diagnosed colon cancer. This trial will help answer those questions and gather evidence to guide future treatment recommendations.
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If you join this study, you will be randomly assigned to take aspirin at one of three different doses for 3 weeks before your scheduled surgery. You will take either 100 mg once daily, 300 mg once daily, or 100 mg twice daily. During this time, researchers will collect blood and urine samples to measure how the medication affects your body and to look for signs of its cancer-prevention effects. The entire study period lasts about 3 weeks, ending when you have your surgery.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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