Understanding Hereditary Spastic Paraplegia Through Yearly Checkups and Biosamples

This is a long-term study that aims to better understand hereditary spastic paraplegia — a rare condition affecting the nerves that control leg movement — by following patients and their families over many years. Researchers will perform standardized clinical exams, collect optional blood or tissue samples, and gather information into a shared database to identify patterns, discover new biomarkers, and understand how the disease progresses.

Hereditary spastic paraplegia is a rare and complex disorder, and doctors still don't fully understand how and why it develops or how to predict its course in individual patients. By collecting information and samples from many patients over time, this study aims to identify new insights into the disease that could eventually lead to better treatments and earlier diagnosis.