Plain-English translation of NCT03983291 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a simple facial exercise program can help treat depression. The idea comes from research showing that our facial expressions don't just show our emotions — they actually influence how we feel. By relaxing the muscles we tense when we're sad or angry, and strengthening the muscles we use when we smile, researchers hope to help people with depression feel better.
Some studies have found that blocking certain facial muscles (using botulinum toxin injections) can reduce depression symptoms. This trial wants to see if the same benefit can be achieved through a gentler, non-invasive approach: facial exercises and massage that anyone can do at home.
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After training from a physiotherapist, you will practice facial exercises at home for 15 minutes every day. Some participants will learn exercises that relax muscles linked to sadness and strengthen muscles linked to happiness, while others will do a resting exercise as a comparison. The study involves about 40 people total, and you would be expected to continue your current depression treatment as usual.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
Switzerland
Sponsor
Zentrum für Angst und Depressionsbehandlung Zürich
Enrollment target
~40 participants
Started
June 2019
Primary completion
March 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 65 Years
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Patricia Waldvogel, PhD
Zentrum für Angst und Depressionsbehandlung Zürich
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.