Plain-English translation of NCT03984461 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether combining platelet-rich plasma (PRP) with fat tissue and/or bone marrow can help treat osteoarthritis—the wear-and-tear damage to joints that causes pain and stiffness. Researchers will inject these healing materials directly into damaged joints to see if they reduce pain and improve how well the joint works. You'll be randomly assigned to receive one of three different combinations, and the study will follow you over time to measure how much your symptoms improve.
Osteoarthritis affects millions of people and current treatments—like steroid injections or surgery—don't work for everyone and may have limitations. This study exists to see whether combining these natural healing materials from your own body might offer a better, longer-lasting option for joint pain.
You likely qualify if…
You likely don't qualify if…
You will receive a single injection of healing materials directly into your arthritic joint. The injection will contain one of three combinations of materials, depending on which group you're randomly assigned to. After the injection, you'll be followed over time with visits and assessments to track your pain, function, and how well the treatment works. The study will involve imaging (X-rays or MRI) and symptom checks at scheduled follow-up visits.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
Canada
Phase
Testing effectiveness
Sponsor
Dr. Grant M. Pagdin
Enrollment target
~240 participants
Started
September 2020
Primary completion
December 2027
Age range
19 Years – 79 Years
Last updated on clinicaltrials.gov in November 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Grant Pagdin, MD
Quorum Review IRB
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.