Plain-English translation of NCT03995121 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers are testing a new brain imaging technique called PET scanning to better understand how brain cells connect in people with schizophrenia, other psychotic disorders, and cannabis use disorder. The scan shows where and how densely brain cells are connected, which may help explain these conditions. This study compares brain scans from people with these conditions to healthy volunteers.
Scientists believe that problems with brain cell connections may play a role in psychiatric disorders like schizophrenia and cannabis use disorder. This new imaging medication may help doctors see these connection problems more clearly, which could lead to better treatments in the future.
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You will receive an injection of the imaging medication through an IV, followed by about 2 hours lying still in a PET scanner while it takes pictures of your brain. You will also complete brain wave tests (EEG) where electrodes on your scalp measure your brain activity while you perform simple tasks. The entire study visit typically takes several hours.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States
Collaborators
National Institute on Drug Abuse (NIDA)
Enrollment target
~250 participants
Started
December 2017
Primary completion
December 2026
Age range
18 Years – 85 Years
Last updated on clinicaltrials.gov in January 2026.
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Central contact
Angerlyk Frytz, MD
Yale University
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