Plain-English translation of NCT03998202 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Colorectal Cancer research guide →This research study is following older adults with metastatic colorectal cancer who are receiving chemotherapy—usually 5-Fluorouracil (5-FU), sometimes combined with other drugs—to understand how muscle loss in the body affects how patients tolerate this treatment and how well they survive. The researchers want to learn why some people experience more severe side effects from chemotherapy than others, and whether genetic differences play a role.
Older adults with cancer often have less muscle mass, which may make them more vulnerable to dangerous side effects from chemotherapy. This study exists to better understand this connection so doctors can predict who is at highest risk and potentially adjust treatment plans to keep patients safer.
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As a participant, you would be part of a research group being followed over time as you receive your standard chemotherapy treatment. You would share your medical information and allow researchers to access your health records, answer questionnaires about your health and activity level, and likely donate blood samples so scientists can study genetic factors that influence how your body responds to treatment. The study is not giving you a new or experimental drug—it is observing and measuring how your body handles the chemotherapy you are already receiving.
AI-generated summary from trial data · Aug 11, 2026 · Not medical advice
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