Recruiting

Testing a skin cream and vitamin supplement together for psoriasis

Plain-English translation of NCT04036188 on ClinicalTrials.gov ↗ · Source last updated February 2026 · Translation generated June 2026 · How we translate trials

Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.

What is this trial?

This trial is testing whether cream—a steroid applied to the skin—works better when paired with daily vitamin D3 supplements for treating plaque psoriasis. Researchers want to see if adding the vitamin D helps improve skin healing beyond what the cream alone can do. The study will follow participants for 28 weeks to measure how much their psoriasis improves.

Psoriasis is a chronic skin condition that can be difficult to treat, and current treatments don't work equally well for everyone. This trial explores whether this medication combined with a common vitamin supplement might offer better results and help more people with psoriasis see improvement.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have been diagnosed with mild to moderate plaque psoriasis affecting at least 2% of your body surface area
you have not used certain psoriasis treatments (like phototherapy or other systemic medications) in the past 4 weeks
you do not have kidney disease, a history of kidney stones, or parathyroid problems

You likely don't qualify if…

you are currently taking certain medications that affect electrolyte balance in your blood
you have taken calcium supplements in the month before joining the study
you have serious uncontrolled medical conditions such as heart disease, lung disease, kidney disease, or liver disease
you have a history of kidney stones, severe kidney problems, or parathyroid abnormalities
you have used other psoriasis medications or light therapy treatments within the past 4 weeks

What participation looks like

All participants will first apply the steroid cream for 4 weeks. Then, half will receive vitamin D3 supplements while the other half receive a placebo for 12 weeks—neither group will know which they're getting. At week 16, everyone will switch to (or continue) taking the vitamin D3 for another 12 weeks. Throughout the 28-week study, you'll visit the clinic periodically so researchers can examine your skin and measure how much your psoriasis has improved.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(1 site)

United States

Wright State Physicians, Fairborn, Ohio