Plain-English translation of NCT04038502 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether the order in which you receive two cancer medications— and —matters for treating advanced prostate cancer that has gotten worse despite other treatments. You'll be randomly assigned to receive one of these medications first, and then switch to the other medication if needed. Both drugs work by targeting cancer cells that have difficulty repairing their DNA.
Researchers want to understand which medication should be given first and which second to get the best results for men with this specific type of prostate cancer. Right now, there isn't a clear answer about the best order, so this study will help doctors make better treatment decisions in the future.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to one of two treatment groups. If you're in the first group, you'll receive as an intravenous infusion every 3 weeks, and if your cancer responds well and later progresses, you'll switch to taking as a pill twice daily at home. If you're in the second group, you'll start with pills at home, and later switch to infusions if needed. Throughout the study, you'll have regular blood tests and imaging to monitor how well the treatment is working and watch for side effects.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United States